methods for modulating cell uptake and / or clearance, for modulating antigen recognition, processing and / or presentation of cell-derived material, for modulating an immune response to cell-derived material, for detecting a cell with a cell membrane disrupted, a cell infected with a pathogen, an agonizing cell or a dead cell, to diagnose, predict and / or monitor the condition of a disease, to monitor therapy, to identify a ligand of a polypeptide, to distinguish between an apoptotic cell and an end-stage apoptotic cell, necrotic cell or dead cell and to modulate an immune response to an ant
The Burnet Institute;Walter And Eliza Hall Institute Of Medical Research
发明人:
David Ching Siang Huang,Irina Caminschi,Jian-Guo Zhang,Ken Shortman,Mark Dexter Wright,Mark Francis Van Delft,Mireille Hanna Lahoud
申请号：
BRPI0912215
公开号：
BRPI0912215A2
申请日:
2009.05.12
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. The present invention further relates to methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
