1. A pharmaceutical composition comprising a plurality of particles comprising at least one digestive enzyme, wherein the particles have low particle sizes. The pharmaceutical composition according to claim 1, wherein the particles have a volumetric diameter d (v, 0.1) of at least about 400 microns and a volumetric diameter of d (v, 0.9) of not more than about 800 microns. The pharmaceutical composition according to claim 1, where these particles have at least one coating, and the particles include: about 40-98 wt.% A mixture of digestive enzymes； about 2-20 wt.% polymer； optionally about 0-30 wt.% inert core and optionally one or more pharmaceutically acceptable excipients. 4. The pharmaceutical composition of claim 3, wherein said particles comprise at least about 60% by weight of a digestive enzyme mixture. The pharmaceutical composition according to claim 3, where these particles are micropellets and have at least one coating, and they include: about 40-98 wt.% A mixture of digestive enzymes； about 2-10 wt.% a water-soluble polymer； optionally about 0-30 wt.% inert core and optionally one or more pharmaceutically acceptable excipients. 6. The pharmaceutical composition according to claim 3, wherein said particles are microgranules and have at least one coating, and they include: about 80-95% by weight of a mixture of digestive enzymes； about 5-20% by weight of a water-insoluble polymer and optionally one or more pharmaceutically acceptable excipients. 7. The pharmaceutical composition of claim 6, wherein the water-insoluble polymer is a co-cured polymer. The pharmaceutical composition according to claim 3, where the coating includes: one or more hydrophilic1. Фармацевтическая композиция, включающая множество частиц, содержащих по меньшей мере один пищеварительный фермент, где частицы имеют низкие величины размера частиц.2. Фармацевтическая композиция по п.1, где частицы имеют объемный диаметр d(v,0.1) не меньше около 400 мкм и объемный диаметр d(v,0.9) не больше
