KILBURN, John Paul,RASMUSSEN, Lars Kyhn,JESSING, Mikkel,ELDEMENKY, Eman Mohammed,CHEN, Bin,JIANG, Yu,HOPPER, Allen T.
申请号：
ES13786633
公开号：
ES2662523T3
申请日:
2013.10.11
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula I ** (See formula) ** wherein R 1 is, pyrimidyl which is optionally substituted with one or more C 1-6 alkyl, halogen, hydroxy, C 1-6 hydroxyalkyl, C 1-4 fluoroalkyl, C 3- cycloalkyl 6, C1-4 alkoxy, C1-4 fluoroalkoxy, cyano or -SO2R8； wherein R2 is C3-6 cycloalkyl, C3-6 cyclohetalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4 alkoxy, C1-6 alkenyl, C1-6 alkynyl, 6 membered heteroaryl, phenyl or C1-4 alkyl optionally substituted with one or more R9； wherein R3 is hydrogen, fluorine, C1-4 alkyl or C1-4 fluoroalkyl； or wherein R2 and R3 combine with the carbon to which they are attached to form cyclohexyl, tetrahydropyranyl, piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, azetidinyl, homomorpholinyl, homopiperidinyl or homopiperazinyl each of which is optionally substituted with one or more C1 alkyl -6, C1-6 alkenyl, C3-6 cycloalkyl, C1-6 alkoxy, oxo, -NR6R7 or fluorine； wherein R4 is halogen, C1-4 fluoroalkyl, cyano, cyclopropyl, C1-4 alkyloxy, C1-4 fluoroalkyloxy, SO2R8, -NR6R7 or C1-6 alkyl； wherein R5 is halogen, C1-6 alkyl, C1-4 fluoroalkyl, cyano, -SO2R8, -NR6R7, C1-6 alkoxy, C1-4 fluoroalkoxy or C3-6 cycloalkyl； wherein R6 and R7 independently of each other are hydrogen or C1-6 alkyl； wherein R 8 is C 1-6 alkyl, C 3-6 cycloalkyl or C 1-4 fluoroalkyl； wherein R9 is C1-6 alkyl, C3-6 cycloalkyl, -NR10R11, C1-4 fluoroalkyl or 3- to 7-membered heterocyclyl which is optionally substituted with one or more C1-6 alkyl, halogen, hydroxy, C1-4 fluoroalkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1-4 fluoroalkoxy or cyano； wherein R10 and R11 independently of each other are hydrogen or C1-6 alkyl； or wherein R10 and R11 combine with the nitrogen to which they are attached to form piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, azetidinyl, homomorpholinyl, homopiperidinyl or homopiperazinyl each of which is optionally substituted with one or more C1-6 alkyl, alkoxy C1-6, oxo or fluorine； and where n is 0-3； or one of its pharmaceutically acceptable
