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HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS
专利权人:
PFIZER INC.
发明人:
BENBOW, JOHN WILLIAM,LOU, JIHONG,PFEFFERKORN, JEFFREY ALLEN,TU, MEIHUA MIKE
申请号:
NZ59136609
公开号:
NZ591366A
申请日:
2009.08.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed are substituted heteroaryl compounds of formula (1A), or a pharmaceutically acceptable salt thereof, wherein the substituents are as described within the specification. Examples of compounds of formula (1A) include: (S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-1H-imidazol-1-yl)-N-(5-methylpyridin-2-yl)propanamide; and (S)-6-(3-cyclopentyl-2-(4-(methylsulfonyl)-1H-imidazol-1-yl)propanamido)nicotinic acid. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (1A), and the use of a compound of formula (1A) in the manufacture of a medicament for treating or delaying the progression of diabetes and/or diabetes-related disorders.
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