תרכובות 7,6– דיהידרופיראזולו[5,1–a]פיראזין–4(5h)–און והשימוש בהן כמאפננים אלוסטרים שליליים של קולטני mglur2

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专利权人:

JANSSEN PHARMACEUTICA NV

发明人:

申请号：

IL24286815

公开号：

IL242868A

申请日:

2015.12.01

申请国别(地区):

IL

年份:

2019

代理人:

摘要：

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (&ldquo；mGluR2&rdquo；). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

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中国工程科技知识中心

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http://www.ckcest.cn/home/