A method for illuminating a treatment target includes providing a medical device and a malleable waveguide, and positioning the medical device and the malleable waveguide into the treatment target. The method also includes deforming the medical device to conform with a native anatomy in the treatment target, and deforming the malleable waveguide to conform with the native anatomy in the treatment target. The deformation of the malleable waveguide cooperates with the deformation of the medical device. The method also includes performing a medical procedure with the medical device and illuminating the treatment target with light from the malleable waveguide.