Various embodiments of the invention relate to the pharmaceutical composition and method for treating disease, the disease includes Focal segmental glomerulosclerosis or pulmonary hypertension.The composition of such embodiment includes activation aliphatic acid, such as alkyl-substituted aliphatic acid, ketofatty acid and nitrofatty acid.The method of various embodiments includes a effective amount of 10 nitro, 9 (E) 18 carbon, 9 olefin(e) acid of application to treat such disease.