Disclosed is a compound of formula (I) such as 5-{ (R)-1-[4-(1-Hydroxy-hexyl)-phenyl]-5-oxo-pyrrolidin-2-ylmethoxymethyl} -thiophene-2-carboxylic acid. And the use of the compounds in the manufacture of a medicament for the treatment of glaucoma or ocular hypertension or for the treatment of inflammatory bowel disease.