COUMARIN-3-CARBOXAMIDE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING UROTENSIN-II RECEPTOR ACTIVITY-RELATED DISEASES CONTAINING COUMARIN-3-CARBOXAMIDE DERIVATIVE AS ACTIVE COMPONENT
The present invention relates to a coumarin-3-carboxamide derivative, a manufacturing method thereof, and a pharmaceutical composition for preventing or treating urotensin-II receptor activity-related diseases containing the coumarin-3-carboxamide derivative as an active component. The derivative acts as an antagonist for an urotensin-II receptor, thereby being able to be usefully used for preventing or treating urotensin-II receptor activity-related diseases such as, congestive heart failure, cardiac ischemia, myocardial infarction, cardiac hypertrophy, cardiac fibrosis, coronary artery disease, arteriosclerosis, hypertension, asthma, kidney failure, diabetes, vasculitis, neurodegenerative diseases, stroke, pain, depression, psychosis, cancer, etc.COPYRIGHT KIPO 2020쿠마린-3-카복시아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 유도체는 유로텐신-Ⅱ 수용체에 대한 길항제로 작용함으로써 울혈성 심부전, 심장 허혈, 심근경색, 심장 비대증, 심장 섬유증, 관상동맥 질환, 동맥경화증, 고혈압, 천식, 신부전, 당뇨병, 혈관염증, 신경퇴행성 질환, 뇌졸중, 통증, 우울증, 정신병, 암 등과 같은 유로텐신-Ⅱ 수용체 활성 관련 질환을 예방 또는 치료하는데 유용하게 사용할 수 있다.
