The present invention generally relates to the field of monocarboxylic acid transport modifiers, such as monocarboxylic acid transport inhibitors, particularly abnormal tissue growth and fibers, including, for example, cancer and other neoplastic disorders, inflammatory diseases, cardiomyopathy Novel in the treatment, modification, prevention and / or alleviation of physiological conditions associated with monocarboxylic acid transport activity, such as treatment of increased disorders, obesity, diabetes, cardiovascular disease, tissue and organ transplant rejection and malaria It relates to the synthesis and use of substituted quinolone compounds, these compounds and their pharmaceutical compositions.本発明は、一般に、モノカルボン酸輸送修飾薬、例えば、モノカルボン酸輸送阻害剤の分野、特に、例えば、がんおよび他の新生物障害、炎症疾患、心筋症を含む、異常組織増殖および繊維増多の障害、肥満、糖尿病、心血管疾患、組織および臓器移植拒絶ならびにマラリアの治療などの、モノカルボン酸輸送活性に関連する生理的条件の治療、修飾、予防および／または軽減における、新規の置換キノロン化合物、これらの化合物およびそれらの薬剤組成物の合成および使用に関する。
