TO 22 FIG. 1 W O 20 18/ 207 105 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT IiiimmomiolollmonolooloionmoionomovoimIE (10) International Publication Number WO 2018/207105 Al (51) International Patent Classification: A61N 5/10 (2006.01) C23C 14/06 (2006.01) A61K 51/12 (2006.01) C23C 14/48 (2006.01) A61K 9/00 (2006.01) (21) International Application Number: PCT/IB2018/053213 (22) International Filing Date: 09 May 2018 (09.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,800 11 May 2017 (11.05.2017) US (71) Applicant: ALPHA TAU MEDICAL LTD. [IL/IL]； School of Physics, Tel Aviv University, P.O. Box 39040, 6997801 Tel Aviv (IL). (72) Inventors: KELSON, Itzhak； 94 Dizengoff Street, 6439606 Tel Aviv (IL). KEISARI, Yona； 8 Hagaon Eliyahu Street, 5236477 Ramat Gan (IL). SCHMIDT, Michael； 7 Eucalyptus Street, 4453507 Kfar Saba (IL). BERKOWITZ, Avia； 34/8 Hasida Street, 7169334 Modiin (IL). MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) Agent: D. KLIGLER I. P. SERVICES LTD.； P. O. Box 57651, 61576 Tel Aviv (IL). Designated States (unless otherwise indicated, for every kind of national
