Olaf Schneewind,Dominique M. Missiakas,Yating Wang
申请号：
US14237320
公开号：
US20140302084A1
申请日:
2012.08.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Production of protein conjugate vaccines by use of transpeptidase enzymes, such as sortase enzymes. For example, homogenous immunoconjugates (e.g., a population of molecules having the same structure) formed by conjugating an antigenic polypeptide and a bacterial capsule component are provided. In certain aspects, methods for generating an immune response to B. anthracis by use of protective antigen-PDGA immunoconjugates are provided.
