JASON R. HARRIS,BRIAN W. METCALF,QING XU,CALVIN W. YEE,STEPHEN L. GWALTNEY,ZHE LI
申请号：
ARP140101046
公开号：
AR095342A1
申请日:
2014.03.14
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
This document deals with appropriate pharmaceutical compounds and compounds that act as modulators of hemoglobin and are used to treat disorders of hemoglobin metaphase and disorders caused by tissue and / or cellular oxygen effects. Claim 1: in some aspects of this contract, a formula compound (1) or one of its tensiometers, or an acceptable salt for each formula, shall be supplied, Features: Ring A is an optional alternative to ring a, consisting of 4 to 10 members, or a heteromorphic cycle consisting of up to 5 heteromorphic atoms composed of 4 to 10 members. In this cycle, heteromorphic atoms are selected from the group consisting of O, N, S.and oxidized forms of N and S； or the B ring is a C₆₋₁₀ aryl or a 5-10 membered heteroaryl with between 1 and 3 nitrogen atoms, preferably between 1 and 2 nitrogen atoms and more preferably 1 nitrogen atom, or its oxidized versions , where aryl or heteroaryl is optionally substituted； ⁻ ⁻ ⁻ ⁻ ⁻ Is a single or double union； each Y and Z is, independently, CR¹⁰R¹¹,O S SO SO NReach R¹⁰ and R¹¹ independently is hydrogen or C₁₋₃ alkyl optionally substituted with halo, OH, or C₁₋₆ alkoxy,or CR¹⁰R¹¹ is C = O； R¹² is hydrogen or C₁₋₆ alkyl；If one between Y and Z is O, s, s o, so832222,then the other is not CO, and provided that Y and Z are not both heteroatoms or their oxidized forms； the ring C is aryl C₆₋₁₀,optionally substituted； V¹ and V² are, independently, C₁₋₆ alkoxy；Or you and youTogether with carbon atoms, they combine to form a formula ring (2),1. Each V3 and v83088 is an independent o, s, or NH, provided that when v8308s and v8308s are s, the other is NH, provided that V3 and v83088 are not two NH； q is 1 or 2； each v8309es, whether c83218326 or co8322； r8310； 83044；where each R⁶⁰ is independently C₁₋₆ alkyl or hydrogen； t is 0, 1, 2, or 4； or CV¹V² is C = V, where V is O, NOR⁸⁰,o NNR⁸¹R⁸²；R⁸⁰ is optionally substituted C₁₋₆ alkyl； R⁸⁰ and R⁸¹,independently, they are selected from the group consisting of hydrogen, optional
