Disclosed is a completely humanized monoclonal neutralizing antibody for a tetanus toxin. The present invention develops a completely humanized anti-tetanus toxin monoclonal neutralizing antibody by means of a comprehensive high-throughput completely humanized monoclonal antibody research and development technical platform. The monoclonal neutralizing antibody can be used for preventing, treating, and detecting clostridium tetanus infection. The completely humanized anti-tetanus toxin monoclonal neutralizing antibody searched and developed in the present invention is high in affinity to the tetanus toxin, and high in neutralizing activity, and safe and efficient, has no exogenous virus contamination, can be widely applied to all kinds of people, and has strong industrial practicality.
