Mitsuko L. Yamamoto,Robert H. Schiestl,Ramune Reliene,James Borneman,Laura L. Presley,Jonathan Braun
申请号：
US15499390
公开号：
US10413577B2
申请日:
2017.04.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner.
