PROBLEM TO BE SOLVED: To provide compounds effective against proliferation or metastasis of cancers, such as pancreatic cancer, ovarian cancer, and breast cancer, as well as in the treatment of inflammatory diseases, by inhibiting MT1-MMP/Mint3 pathway that activates HIF specifically, because a method for directly inhibiting hypoxia inducible factor (HIF) is not developed.SOLUTION: A Mint3 inhibitor contains e.g., a compound obtained by the reaction that is illustrated below, or a pharmacologically acceptable salt thereof.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】低酸素誘導因子(HIF)を直接阻害する方法は開発されていないのでHIFを特異的に活性化するMT1-MMP/Mint3パスウェイを阻害することによる、膵癌、卵巣癌、乳癌等の癌の増殖や転移、並びに、炎症性疾患の治療に有効な化合物の提供。【解決手段】例えば下記に例示する様な反応により得られる化合物、又はその薬理学的に許容される塩を含有するMint3阻害剤。【選択図】なし
