RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA)

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专利权人:

Victoria Pickering;Jyoti K. Shah;Walter Strapps

发明人:

Victoria Pickering,Jyoti K. Shah,Walter Strapps

申请号：

US13255725

公开号：

US20120029054A1

申请日:

2010.03.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of GATA3 gene expression and/or activity, and/or modulate a GATA3 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsR-NA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against GATA3 gene expression.

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