The invention is directed to a method of treating or reducing the risk of intrahepatic cholestasis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising at least one bacterial species or strain comprising bile acid deconjugation/hydrolysis activity and/or 7-epimerization activity, thereby treating or reducing the risk of intrahepatic cholestasis in a subject in need thereof. Compositions for use in such methods are also provided.
