PROCEDES DE CRIBLAGE DE MODULATEURS D'UNE ACTIVITE BIOLOGIQUE DE TYPE GDF15

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专利权人:

JANSSEN BIOTECH; INC.

发明人:

ARMSTRONG, ANTHONY,BECK, STEPHEN,CHAVEZ, JOSE ANTONIO,CHIN, CHEN-NI,DINH, THAI,FURMAN, JENNIFER,HUSOVSKY, MATT,LIN-SCHMIDT, XIEFAN,MULLICAN, SHANNON,RANGWALA, SHAMINA,SOUTH, VICKI

申请号：

CA3038846

公开号：

CA3038846A1

申请日:

2017.10.11

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/