The present invention provides compositions, systems, and methods employing materials to reduce or eliminate vapor transfer of an active substance from a target surface to a non-target surface. In certain embodiments, a material is mixed with a liquid, gas, and/or solid comprising an active substance to form a mixture such that the mixture has a lower vapor pressure than the liquid, gas, and/or solid. In some embodiments, the active substance is a herbicide and the target surface is an agricultural field or crop.