PROBLEM TO BE SOLVED: To provide a material for promoting CGRP (calcitonin gene-related peptide) responsiveness of cells.SOLUTION: There is provided the CGRP responsiveness promoter of cells containing at least one substance selected from the group consisting of butcher's broom, Amur corktree, Hemerocallis fulva, rose balsam, fucoid, birch, rice protein, rice oil, Aloe vera, root sheath of Paeonia moutan, laminaria, star fruit, cornflower, lemon grass, apricot kernel, lemon, sweet marjoram, marronnier, royal jelly, rose hip and their extracts as an active component.