NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS

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专利权人:

SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

发明人:

PELLECCHIA MAURIZIO

申请号：

ZA201107274

公开号：

ZA201107274B

申请日:

2011.10.05

申请国别(地区):

ZA

年份:

2012

代理人:

摘要：

Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

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