N N bis hidroksietil glicin amid kot linker vpolimerno konjugiranih predzdravilih

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专利权人:

ASCENDIS PHARMA A/S

发明人:

VETTER DIRK,RAU HARALD,WEGGE THOMAS,HERSEL ULRICH

申请号：

SI200631452

公开号：

SI1909845T1

申请日:

2006.06.21

申请国别(地区):

SI

年份:

2012

代理人:

摘要：

A polymeric prodrug is described which comprises at least one polymer attached via at least one permanent bond to a bicine linker. The bicine linker is attached via a temporary linkage to an amine containing biologically active moiety. The amine containing biologically active moiety&mdash；such as a drug&mdash；can be released by cleaving the temporary linkage.

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