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METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS
专利权人:
РАЙДЖЕЛ ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
СИНГХ Раджиндер (US),АРГАДЕ Анкуш (US),ПЭЙАН Дональд Дж. (US),КЛАФ Джеффри (US),КАЙМ Холгер (US),СИЛВЭН Катрин (US),ЛИ Хуэй (US),БХАМИДИПАТИ Сомасекхар (US)
申请号:
RU2013123881/04
公开号:
RU2013123881A
申请日:
2013.05.24
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. The 2,4-pyrimidinediamine compound for use in the treatment of autoimmune diseases other than ulcerative colitis, Crohn's disease, inflammatory bowel disease and idiopathic inflammatory bowel disease, where the 2,4-pyrimidinediamine compound is: a compound of structural formula (I): or its salt, hydrate, solvate and / or N-oxide, where: L1 and L2 are each a direct bond; R2 is selected from the group consisting of the following: phenyl mono substituted at the 3- or 5-position with the help of the group R8, phenyl di or tri-substituted by one or several with identical or different groups of R8 and optionally substituted heteroaryl as defined below; R4 is selected from the group consisting of the following: phenyl substituted with one or more identical or different R 8 groups and optionally substituted heteroaryl as defined below; characterized in that for R2 and R4, each of these optionally substituted heteroaryls, independently of one another, are selected from the group consisting of: where p is an integer from one to three; each independently represents a single bond or double th bond; R35 is hydrogen or R8; X is selected from the group consisting of CH, N and NO; each Y is independently selected from the group consisting of O, S and NH; each Y1 is independently selected from the group consisting of O, S, SO, SO2, SONR36, NH, and NR37; each Y2 is independently selected from the group consisting of CH, CH2, O, S, N, NH, and NR37; R36 is hydrogen or alkyl; R37 is selected from the group consisting of hydrogen and progroup, selected from the group consisting of the following: aryl, arylalkyl, heteroaryl, R, R, -CRR-OC (O) R, -CRR-O-PO (OR), -CH-O-PO (OR), -CH- PO (OR), -C (O) -CRR-N (CH), -CRR-OC (O) -CRR-N (CH), -C (O) R, -C (O) CF and -C (O ) -NR-C (O) R; R38 is selected from the group consisting of alkyl1. Соединение 2,4-пиримидиндиамина для применения в лечении аутоиммунных заболеваний, отличных от язвенного колита, болезни Крона, воспалительная болезнь кишечни
来源网站:
中国工程科技知识中心
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