ARYLSULFONYLMETHYL OR ARYLSULFONAMIDE SUBSTITUTED AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR
DRESCHER, KARLA,HAUPT, ANDREAS,UNGER, LILIANE,TURNER, SEAN, C
申请号：
NZ58964905
公开号：
NZ589649A
申请日:
2005.10.14
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are aromatic sulfonyl compounds of formula I, being either arylsulfonylmethyl or arylsulfonamide compounds, and methods for their preparation. The compounds are dopamine D3 receptor ligands. Specific examples of compounds of formula I are: 4-Isopropyl-N-((R)-6-propylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide, (R)-N-[5-(4-Isopropyl-benzenesulfonylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-propionamide, N-((S)-6-Allylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-4-isopropylbenzenesulfonamide, hydrochloride, and N-[3-(4-Trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-7-yl]-propionamide. Also disclosed is the use of compounds of formula I for treating central nervous system diseases such as addiction.
