WYTHES, MARTIN JAMES,TRAN-DUBE, MICHELLE BICH,TATLOCK, JOHN HOWARD,RUI, EUGENE YUANJIN,PATMAN, RYAN,MTIGUE, MICHELE ANN,MALPINE, INDRAWAN JAMES,KUMPF, ROBERT ARNOLD
申请号：
ARP170101535
公开号：
AR108763A1
申请日:
2017.06.05
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a compound characterized by the formula (1) or a Salt of the pharmaceutical acceptable from the point of view, where r\u00b9: selected from the group consisting c\u2081\u208b\u2088alquilo,C\u2081\u208b\u2088haloalquilo, Hydroxy, c\u2081\u208b\u2088alcoxi, c\u2085\u208b\u2081\u2082arilo heteroaryl, 5 - 12 members, c\u2083\u208b\u2081\u2080cicloalquilo, heterociclilo 3 - 12 members, or\u2074, sr\u2074 and N (r\u2074) \u2082, where each is independently r\u2074 - r\u00b9\u2074,Where is absent, is c\u2081\u208b\u2083alquilo, - C (o) - O - SO\u2082 -, and r\u00b9\u2074 is Hydrogen, c\u2081\u208b\u2088alquilo, c\u2085\u208b\u2081\u2082arilo heteroaryl, 5 - 12 members, c\u2083\u208b\u2081\u2080cicloalquilo or heterociclilo 3 - 12 membersOr two r\u2074 Unite to form a Heterocyclic Ring containing members of 4 - 6 1 - 3 heteroatoms selected from N, o and S R\u00b2 is Hydrogen, halogen, Hydroxy, c\u2081\u208b\u2088alquilo,C\u2081\u208b\u2088alcoxi or N (r\u2075 \u2082), where each r\u2075 is independently Hydrogen or c\u2081\u208b\u2088alquilo,Or two r\u2075 Unite to form a Heterocyclic Ring containing members of 4 - 6 1 - 3 heteroatoms selected from N, o and S r\u00b3 each is selected independently Hydrogen, Hydroxy,Nh\u2082 c\u2081\u208b\u2088alquilo or heteroalquilo has 1 - 8 ATOMS, or when d is C (r\u00b3) \u2082, r\u00b3 also Selects FluorineC\u2081\u208b\u2088alquileno or heteroalquileno bonded to an Atom in g to form a Ring FUSED to gWhere r\u00b3 is replaced with optional 1 - 6 r\u2078 r\u2079 each is independently Hydrogen or Fluorine d is C (r\u00b3) \u2082 nr\u00b3, o, S, or s (OR) is a c\u2085\u208b\u2081\u2082arilo \u2081\u208b\u2082 g,Or a heteroaryl Ring System of 5 - 12 membersA FUSED Ring system or c\u2083\u208b\u2081\u2080cicloalquilo heterociclilo each r\u2078 is absent or is selected from the group consisting c\u2081\u208b\u2088alquilo Regardless, c\u2081\u208b\u2088haloalquilo, Hydroxy,C\u2081\u208b\u2088alcoxi, c\u2085\u208b\u2081\u2082arilo het
