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FACTOR VIII SEQUENCES
专利权人:
发明人:
Amit Nathwani,Jenny McIntosh,Edward Tuddenham,Andrew Davidoff
申请号:
US15254984
公开号:
US20170049859A1
申请日:
2016.09.01
申请国别(地区):
US
年份:
2017
代理人:
摘要:
There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide sequence encoding for the B domain of the factor VIII protein is between 90 and 111 nucleotides in length and encodes for an amino acid sequence comprising a sequence having at least 85% identity to SEQ ID NO: 4 and which comprises six asparagine residues. Also provided is a functional factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating haemophilia, e.g. haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.
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