Refers to compounds derived from biciclicas lactams of formula (i) wherein R1, X, Z, L, N, The Ring, The Ring B and C Ring are as described in the present document.Preferred compounds are: (S) - N - (4 - methyl - 5 - oxo - 5,6,7,8-tetrahydro - 5h pyrazolo [1,5-a] [1,3] diazepin - il - 6 - 4 - 1 - Benzyl - fenoxipicolinamida n - (1 - methyl - 2 - oxo - hexahidroimidazo [1,2,3,4,5,6 1.5 - [1],3 - 3 - il) diazocin] - 1h-1,2,4-triazole - 3 - carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Protein that interacts with the receptor kinase 1 (RIP1) being useful in the treatment of irritable bowel Disorder, Crohns disease,Ulcerative colitisSE REFIERE A COMPUESTOS DERIVADOS DE LACTAMAS BICICLICAS DE FORMULA (I) EN DONDE R1, X, Z1, L, n, EL ANILLO A, EL ANILLO B Y EL ANILLO C SON TAL COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO. SON COMPUESTOS PREFERIDOS: (S)-N-(4-METIL-5-OXO-5,6,7,8-TETRAHIDRO-4H-PIRAZOLO[1,5-a][1,3]DIAZEPIN-6-IL)-4-FENOXIPICOLINAMIDA 1-BENCIL-N-(1-METIL-2-OXO-1,2,3,4,5,6-HEXAHIDROIMIDAZO[1,5-a][1,3]DIAZOCIN-3-IL)-1H-1,2,4-TRIAZOL-3-CARBOXAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUE INTERACTUA CON EL RECEPTOR 1 (RIP1) CINASA SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL INTESTINO IRRITABLE, ENFERMEDAD DE CROHN, COLITIS ULCEROSA
