The self-locking screwdriver includes a guide tube inside which a clamping rod is guided and rotatably driven, one end of which is provided with a cavity which allows the rotational drive and tightening of an anchoring screw, ensuring the immobilization of an orthopedic implant against an osseous body of an individual, the screwdriver including, on the one hand, between The guide tube and the clamping rod, a blocking system cooperating with the guide tube in order to prevent the latter from being loosened from the orthopedic implant when the anchoring screw is tightened and, on the other hand, on the outer periphery of the guide tube, a gripping wheel for locking and/or unlocking the blocking system and the rotational drive of the guide tube.