The present invention involves a sterilizable syringe that allows for reduction in needlestick injuries using conventional sterile needles. The syringe allows for direct access to and the safe removal and disposal of needles. The device consists of a sterilizable, reusable hypodermic syringe (10) to which a disposable needle (18) is attached, and employs carpules (12) containing injectable medication, viewable and either manually or automatically aspirating. Some embodiments have a protective sliding mechanism consisting of an open frame (50) bearing one or more protective collars (60, 61, 62), one at the furthermost end of the frame and an optional second one or more at a more proximal position. The protective mechanism may be extended to protect an exposed needle tip and retracted during an injection. With the protective mechanism extended, the needle mounting hub is exposed to allow for its exchange or removal and safe disposal. The protective mechanism is engaged until immediately prior to the delivery of medication, disengaged on delivery, and engaged after delivery.