COPE, MICHAEL J.,MANSKY, PAUL,LIU, FUTIAN,CHANG, HAN-TING,CHARMOT, DOMINIQUE,CONNOR, ERIC,BIYANI, KALPESH,LIU, MINGJUN,MONG, TONY KWOK-KONG,CHEN, YAN
申请号：
CA2624170
公开号：
CA2624170C
申请日:
2006.10.02
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides methods and compositions for the treatment ofion imbalances using core-shell composites and compositions comprising suchcore-shell composites. In particular, the invention provides core-shellparticles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and ineach case, pharmaceutical compositions thereof. Methods of use of thepolymeric and pharmaceutical compositions for therapeutic and/or prophylacticbenefits are also disclosed. The compositions and methods of the inventionoffer improved approaches for treatment of hyperkalemia and other indicationsrelated to potassium ion homeostasis, and for treatment of hypertension andother indicates related to sodium ion homeostasis.
