Tsuneo Yasuma,Akira Mori,Masahiro Kawase,Hiroyuki Kimura,Masato Yoshida,Albert Charles Gyorkos,Scott Alan Pratt,Christopher Peter Corrette
申请号：
US14089747
公开号：
US09447100B2
申请日:
2013.11.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
There is provided a calcium receptor modulator comprising a compound of the formula (I):wherein ring A is an optionally substituted 5- to 7-membered ring； ring B is an optionally substituted 5- to 7-membered heterocyclic ring； X1 is CR1, CR1R2, N or NR13； X2 is N or NR3； Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7； Ar is an optionally substituted cyclic group； R is H, an optionally substituted hydrocarbon group, etc.； and is a single bond or a double bond； R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group； or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III):wherein ring A is an optionally substituted 5- to 7-membered ring； Q is C, CR5 or N； R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided.Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
