PROBLEM TO BE SOLVED: To provide a tissue regeneration material capable of improving the supply of oxygen and nutrients and the discharge of carbon dioxide and waste matter a manufacturing method thereof and a scaffold for tissue regeneration material.SOLUTION: The tissue regeneration material, i.e. a tissue regeneration material 1 for use in medical treatment, comprises a scaffold 10 for tissue regeneration material including a molded three-dimensional porous and hollow skeleton 12 having biocompatibility and biodegradability a cell layer 31 formed on the scaffold 10 for tissue regeneration material, having at least target cells and a bioactive substance-containing layer 30 which includes at least any one of an adhesion factor for improving the adhesion ratio of the target cells, a growth factor for improving the take ratio, and a growth factor for accelerating the growth of vascular endothelial cells after transplant.【課題】酸素・栄養の供給および二酸化炭素・老廃物の排出を改善できる組織再生体およびその製造方法、並びに組織再生体用足場を提供する。【解決手段】本発明に係る組織再生体は、再生医療用に用いられる組織再生体1であって、生体適合性および生分解性を示す造形体により構成された三次元多孔中空骨格12からなる組織再生体用足場10と、組織再生体用足場10に形成され、少なくともターゲット細胞を有する細胞層31と、少なくともターゲット細胞の接着率を高める接着因子、生着率を高める成長因子および移植後の血管内皮細胞の成長を促進する成長因子の少なくともいずれかを含む生理活性物質含有層30とを具備する。【選択図】図5
