BROADBENT, NICK,布罗德班特尼克,布羅德班特尼克,IMMERZEEL, JEROEN,伊莫尔吉耶杰瑞恩,伊莫爾吉耶傑瑞恩,PROCYSHYN, CHRISTOPHER A.,波拉西席恩克里斯多夫Ａ,GOLD, ROSS M.,哥德罗斯Ｍ,哥德羅斯Ｍ,PARK, STEVE SANG JOON,朴史提夫桑俊,波拉西席恩克里斯多夫A,哥德罗斯M,哥德羅斯M
申请号：
TW103128134
公开号：
TWI638650B
申请日:
2014.08.15
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.在一大體態樣中，本發明揭示一種用藥物產品裝填多個容器之方法，該方法包含：在移送腔室中對密封巢套材料去汙；自密封巢套材料移除固持多個容器的容器巢套及固持多個閉合件的閉合件巢套之一或兩者；將所移除巢套自移送腔室移送至受控的環境封閉體系；用藥物產品無菌裝填容器；及用多個閉合件封閉容器。巢套經配置以允許多個閉合件及容器同時同心對準及同時封閉。閉合件巢套上的彈簧負載保持結構允許在對應多個容器上方可釋放地保持多個閉合件。在一些實施例中，將彈簧負載特徵結構與閉合件巢套單體整合。在藉由閉合件巢套可釋放地保持密封閉合件的同時，可在部分密封的容器中凍乾產品。
