Rohan Fernandes,Matthieu F. Dumont,Raymond W. Sze,Laurie S. Conklin,Hilary A. Hoffman,Jyoti K. Jaiswal
申请号：
US15390106
公开号：
US09987378B2
申请日:
2016.12.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.
