A portable moxibustion therapy device includes a main body 20, having a top opening 21, a sidewall 22 and a bottom 23, and the sidewall 22 comprises a plurality of holes 24 on the sidewall 22 of the main body 20; a cover 30 for opening and closing the top opening 21 of the main body 20; a moxa container 40 which is substantially cylindrical and made of yellow soil in the main body 20; a cylindrical support 50 made of yellow soil placed the moxa container 40 blow in the main body 20; and a gauze 60 located between the moxa container 40 and the cylindrical support 50 in the main body 20. The portable moxibustion therapy device includes a plurality of holes to supply air or oxygen to the moxa 90.