PROBLEM TO BE SOLVED: To provide a serotonin receptor antagonist-containing percutaneous absorption preparation that has a high skin permeation rate and a short lag time and maintains its properties even after storage.SOLUTION: A percutaneous absorption preparation contains (a) a serotonin receptor antagonist, (b) a higher fatty acid ester having no hydroxy groups, and (c) at least one component selected from the group consisting of a C8-C16 aliphatic alcohol and a polyoxyethylene C8-C16 alkyl ether.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】高い皮膚透過速度と短いラグタイムを有し、かつ保存後もその性質を維持するセロトニン受容体拮抗薬含有経皮吸収製剤の提供。【解決手段】(a)セロトニン受容体拮抗薬、(b)ヒドロキシ基を有しない高級脂肪酸エステル、並びに(c)C8-C16脂肪族アルコール及びポリオキシエチレンC8-C16アルキルエーテルからなる群から選択される少なくとも1種の成分を含有する経皮吸収製剤。【選択図】なし