As for this invention, using the antagonist of SERPINE2 and SERPINE2, revelation of the collagen 1A1 in the lung tissue bud cell and/or it includes manner and the constituent which revelation of the smooth muscle actin it makes increase or makes decrease, or. In addition, this invention includes manner and the constituent which formation of the muscle tissue bud cell it makes increase or makes decrease, or. Furthermore, this invention offers the manner and the constituent for remedying the lung disease such as the happening suddenly Characteristic lung tissue symptom and the chronic blockade Characteristic lung disease.< Choice figure >Drawing 1本発明は、SERPINE2およびSERPINE2のアンタゴニストを使用して、肺線維芽細胞におけるコラーゲン1A1の発現および/またはα-平滑筋アクチンの発現を増大または減少させる方法および組成物を包含する。また、本発明は、筋線維芽細胞の形成を増大または減少させる方法および組成物を包含する。さらに、本発明は、特発性肺線維症および慢性閉塞性肺疾患といった肺疾患の治療のための方法および組成物を提供する。【選択図】図1