BASTEN, JOHANNES EGBERTUS MARIA,VAN BOECKEL, CONSTANT ADRIAAN ANTON,BUIJSMAN, ROGIER CHRISTIAN,DREFF-TROMP, CORNELIA MARIA
申请号：
HU0102764
公开号：
HU229088B1
申请日:
1999.06.11
申请国别(地区):
HU
年份:
2013
代理人:
摘要：
The present invention relates to compounds of formula (1), wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which groups may optionally be substituted with one or more substitutents selected from (1-8C)alkyl or (1-8C)alkoxy； R2 and R3 are independently H or (1-8C)alkyl； R4 is (1-8C)alkyl or (3-8C)cycloalkyl； or R3 and R4 together with the nitrogen atom to which they are bonded are a nonaromatic (4-8)membered ring optionally containing another heteroatom, the ring optionally being substituted with (1-8C)alkyl or SO2-(1-8C)alkyl； Q is a spacer having a chain length of 10 to 70 atoms； and Z is a negatively charged oligosaccharide residue comprising two to six monosaccharide units, the charge being compensated by positively charged counterions； or a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention have antithrombotic activity an can be used in treating or preventing thrombin-related diseases.
