National Institute Of Pharmaceutical Education And Research (NIPER)
发明人:
申请号：
EP13724871.2
公开号：
EP2822539B1
申请日:
2013.03.07
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a method of preparation of discrete particles of nanocrystalline solid dispersion, wherein said discrete particle comprises crystals of said active ingredient(s) in the matrix of the said crystallization inducer(s) and/or coexisting with crystals of crystallization inducer(s), optionally along with pharmaceutically acceptable excipient(s). An active ingredient and crystallization inducer is dissolved in a solvent or solvent mixture and then dried to obtain discrete particles of 0.5 to 20 micron size. Each particle consists of crystals of active ingredient in the range of 10-1000 nm dispersed in the matrix of crystallization inducer.
