MOFFAT DAVID CHARLES FESTUS,PINTAT STEPHANE,DAVIES STEPHENE
申请号：
IN6640/CHENP/2008
公开号：
IN278314B
申请日:
2008.12.03
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
ABSTRACT Compounds of formula (I) are inhibitors of p38 MAP kinase, and are tlierefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: wherein: G is -N= or -CH= D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members R6 is hydrogen or optionally substituted C1-C3 alkyl P represents hydrogen and U represents a radical of formula (lA) or U represents hydrogen and P represents a radical of formula wherein A represents an optionally substituted divalent mono- or bicyciic carbocyciic or heterocyclic radical having 5 -13 ring members z, Y, L1 and X1are as defined in the specification R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group and R2 is the side chain of a natural or non-natural alpha amino acid.
