БЬЮТНЕР Грегори Л.,УЭНСЛОУ Роберт М. Мл.,ЧОИ Эрик Дж.,ШУЛЬТЦ Клинтон Скотт,СКОТТ Джереми,АРРЕДОНДО Хуан Д.,АРТИНО Лаура
申请号：
RU2014110399
公开号：
RU2014110399A
申请日:
2012.08.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Compound A, having a shape selected from the group consisting of: a) hydrate III, where III is characterized by a hydrate, or (i) X-ray powder diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in degrees of about 20.5, 5 0 and 18,2 or (ii) a solid-phase carbon-13 CPMAS NMR, containing peaks at about 5.14, 6.31, 12.49, 18.35, 26.81, 28.03, 30.33, 31.27, 34.95 , 35.99, 38.68, 42.01, 54.93, 56.39, 60.14, 74.20, 107.02, 120.11, 121.60, 129.73, 134.35, 135 95, 142.89, 148.47, 155.37, 157.32, 160.90, 168.32, 172.17 and 175.53 ppm b) II-hydrate, hydrate II which is characterized by a powder X-ray diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in degrees of about 11.7, 16.6 and 11,2 c) a crystalline Na salt characterized by a powder X-ray diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in g Radus approximately 18.4, 9.1 and 9,8 d) crystalline K salt characterized by a powder X-ray diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in degrees of about 18.2, 20.3 and 8.9 e) i-hydrate, hydrate i is characterized wherein or (i) X-ray powder diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in degrees of about 8.6, 20.6 and 26.6 or (ii) a solid-phase carbon-13 CPMAS NMR, containing peaks at about 4.22, 7.23, 11.45, 17.79, 24.04, 26.95, 28.29, 31.15, 32.47 , 32.47, 33.46, 34.03, 35.74, 42.32, 53.50, 56.05, 56.96, 77.49, 108.95, 119.65, 122.55, 131 05, 133.13, 135.38, 142.28, 150.78, 156.03, 157.99, 161.36, 171.40, 173.42, 174.30 ppm f) hydrate IV, IV where hydrate or characterized (i) X-ray powder diffraction pattern obtained using copper Kizluchenie which comprises 2θ values in degrees of about 14.7, 11.5 and 7.1 or (ii) solid1. Соединение A, имеющее форму, выбранную из группы, состоящей из:a) гидрата III, где гидрат III характеризуется или (i) порошковой рентгеновской дифрактограммой, полученной, применяя медь K
