The present disclosure relates to one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for selectively inhibiting one or more kinases in one or more tissues. Embodiments of the present disclosure can be used as a therapy or a treatment for a subject where the selective inhibition of kinases with endogenously produced antagonists of kinases may be useful in treating conditions such as cancer, autoimmune disease, and transplant rejection.