hnRNP A1 knockout animal model and use thereof

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专利权人:

发明人:

Yung-Fu Chang,Ting-Yuan Liu,Yuh-Jyh Jong,Jan-Gowth Chang

申请号：

US14092678

公开号：

US08946503B2

申请日:

2013.11.27

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided.

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中国工程科技知识中心

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