A device for implanting a prosthesis 12 in a body tissue equipped with a tubular element 7, within which a prosthesis 12 can slide, and a pressure element 16 for moving said prosthesis 12. The device also comprises a cartridge 5 provided with a seat 31 at its interior, such seat housing the prosthesis 12 and movable under the action of a pusher element 13 from a first position, in which the seat 31 is not facing the tubular element 7, to a second position, in which the seat 31 is in communication with the tubular element 7 in order to allow the insertion of the prosthesis 12 inside the tubular element 7 upon command of the pressure element 16.