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AGENT FOR OCCLUSION OF TISSUES
专利权人:
3-Д МАТРИКС; ЛТД. (JP)
发明人:
ТАКАМУРО Кентаро (JP),ГОДЗО Сатоси (JP),КОБАЯСИ Сатору (JP)
申请号:
RU2011118341/15
公开号:
RU2011118341A
申请日:
2009.10.06
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An agent for tissue occlusion containing a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with hydrophilic amino acids and hydrophobic amino acids linked alternately, and is a self-assembled peptide showing a β-structure in an aqueous solution at physiological pH and / or in the presence of a cation. ! 2. The tissue occlusion agent according to claim 1, in which the peptide has a repeating sequence, which is a sequence consisting of arginine, alanine, aspartic acid and alanine, a sequence consisting of isoleucine, glutamic acid, isoleucine and lysine, or a sequence consisting of lysine, leucine, aspartic acid and leucine. ! 3. The tissue occlusion agent according to claim 1 or 2, wherein the peptide consists of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3.! 4. Agent for tissue occlusion according to claim 1 or 2, additionally containing a low molecular weight drug. ! 5. Agent for tissue occlusion according to claim 3, additionally containing a low molecular weight drug. ! 6. The tissue occlusion agent according to claim 4, wherein the low molecular weight drug is selected from the group consisting of glucose, sucrose, purified sucrose, lactose, maltose, trehalose, dextran, iodine, lysozyme chloride, dimethyl isopropylazulene, tretinoin, tocopheryl, povidone- iodine, alprostadil alfadex, anise alcohol, isoamyl salicylate, α, α-dimethylphenylethyl alcohol, bacdanol, chelional, silver sulfazine, sodium bucladesine, alprostadil alfadex, gentamicin sulfate, tetracycline hydrochloride, sodium1. Агент для окклюзии тканей, содержащий в себе пептид, при этом пептид представляет собой амфифильный пептид, имеющий 8-200 аминокислотных остатков с гидрофильными аминокислотами и гидрофобными аминокислотами, связанными попеременно, и представляет собой самособирающийся пептид, демонстрирующий β-структуру в водном растворе при физиологическом рН и/или в присутствии катиона. ! 2. Агент для окклюзии тканей по п.1, в
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