BRAVO GONZALEZ, Roberto Carlos,BUSER, Thomas,GOUTTE, Frederic Jean-Claude,WASEH BASIT, Syed Abdul,OLIVEIRA VARUM, Felipe Jose,FREIRE, Ana Cristina
申请号：
PE2019000231
公开号：
PE20190625A1
申请日:
2013.04.29
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to the preparation of a delayed release agent, including (a) a nucleon containing the agent； and (b) a coating of a core, including a shell and at least one layer between the core and the shell, consisting of an insulating layer and an inner lining layer. Terior, in which (1) the shell is composed of a mixture of the first polygonal substances that may be attacked by colonial bacteria, which may be starch, amilorosa, amilorop, etc., and a mixture of the second polygonal substance with a pH value of 6 or higher； (2) the middle layer. IOR includes a third polymer, which is a non-ionizing polymer.And there is at least one additive selected from the buffer and the substrate； and (3) the insulating layer includes non-ionizing polymers, such as methyl cellulose, hydroxypropyl cellulose and so on. This formula allows rapid release of pharmacists when they are exposed to colonial conditions and reduces or eliminates the effects of food and/or alcohol on post-drug release.SE REFIERE A UNA FORMULACION DE FARMACO DE LIBERACION RETARDADA QUE COMPRENDE A) UN NUCLEO QUE COMPRENDE EL FARMACO； Y B) UN RECUBRIMIENTO PARA EL NUCLEO, EL CUAL COMPRENDE UNA CAPA EXTERIOR Y AL MENOS UNA CAPA ENTRE EL NUCLEO Y LA CAPA EXTERIOR QUE CONSISTE EN UNA CAPA DE AISLAMIENTO Y UNA CAPA INTERIOR, DONDE i) LA CAPA EXTERIOR COMPRENDE UNA MEZCLA DE UN PRIMER MATERIAL POLIMERICO QUE ES SUSCEPTIBLE A ATAQUES POR PARTE DE BACTERIAS COLONICAS QUE PUEDE SER ALMIDON, AMILOSA, AMILOPECTINA, ENTRE OTROS, Y UN SEGUNDO MATERIAL POLIMERICO QUE TIENE UN UMBRAL DE PH 6 O SUPERIOR, ii) LA CAPA INTERIOR COMPRENDE UN TERCER MATERIAL POLIMERICO QUE ES UN POLIMERO NO IONICO, Y AL MENOS UN ADITIVO SELECCIONADO DE UN AGENTE AMORTIGUADOR Y UNA BASE, Y iii) LA CAPA DE AISLAMIENTO COMPRENDE UN POLIMERO NO IONICO, QUE AL IGUAL QUE LA CAPA INTERIOR PUEDE SER METILCELULOSA, HIDROXIPROPILCELULOSA, ENTRE OTROS. DICHA FORMULACION PERMITE LA LIBERACION ACELERADA DEL FARMACO CUANDO SE EXPONE A CONDICIONES COLONICAS Y LA R
