Methods for preventing and/or treating flavivirus infection are disclosed. The method comprises administering to a subject in need thereof a composition comprising: a) a dopamine D2 receptor antagonist in an amount effective for preventing and/or treating flavivirus infection and b) a pharmaceutically acceptable carrier. The dopamine D2 receptor antagonist may be selected from the group consisting of prochlorperazine or a salt thereof, and haloperidol.本發明係揭露一種預防及/或治療黃質病毒屬病毒感染之方法。該方法包含將一組成物施予一需要的個體,該組成物包含:a)一有效劑量之多巴胺D2受體拮抗劑,以預防及/或治療黃質病毒屬病毒感染;以及b)一藥學上可接受之載體。該多巴胺D2受體拮抗劑係可選自於由普氯苯噻肼(prochlorperazine)或其鹽類、以及哈泊度(haloperidol)所組成之群組。