A composition for delivering a therapeutic or diagnostic agent to a mammalian disease area comprising a therapeutically or diagnostically effective amount of a pharmaceutical composition comprising a therapeutic or diagnostic agent coupled to a SPARC binding polypeptide (SBP) and a pharmaceutically acceptable carrier, wherein SBP includes SEQ ID NOs: 1- 112 and 117.2. The composition of claim 1, wherein the SBP is included. at least 10 consecutive amino acids from any one of SEQ ID NOs: 1-112, or at least 10 consecutive amino acids from two or more of SEQ ID NOs: 1-112.3. The composition of claim 1, wherein the SBP comprises one or more of SEQ ID NOs: 1-5.4. The composition of claim 1, wherein the SBPs are two or more separate polypeptides and the SBPs include. at least 10 consecutive amino acids from any one of SEQ ID NOs: 1-5 or b. at least 10 consecutive amino acids from two or more of SEQ ID NOs: 1-5.5. The composition of claim 1, wherein the SBP comprises at least 10 consecutive amino acids from SEQ ID NO: 117.6. The composition of claim 1, wherein there are two or more separate SBPs, where each individual SBP comprises at least 10 consecutive amino acids from any one of SEQ ID NOs: 1-112.7. The composition according to claim 1, where there are two or more separate SBPs, where individual SBPs include one or more SEQ ID NOs: 1-5 or 117.8. The composition according to any one of claims 1 to 7, wherein the therapeutic or diagnostic agent is an agent selected from the group consisting of platinum compounds, antifolates, antimetabolites, antimitotics, DNA damaging agents, proapoptotics, differentiating agents, antiangiogenic agents, antibiotics thyro1Композиция для доставки терапевтического или диагностического агента в область заболевания млекопитающего, включающая терапевтически или диагностически эффективное количество фармацевтической композиции, включающей терапевтический или диагностический агент, соединенный со SPARC-связывающим полипептидом (SBP) и фармацевт
