The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degarelix, its protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degarelix itself.Degarelix can be obtained by subjecting a Degarelix precursor according to formula II: (P1)AA1-AA2-AA3-AA4(P4)-AA5-AA6(P6)-AA7-AA8(P8)-AA9-AA10-NH2 (II)or a salt or solvate thereof,to a treatment with a cleaving agent in an organic solvent,whereinP1 is an amino protecting groups preferably acetylP4 is hydrogen or a hydroxyl protecting group, preferably a hydroxyl protecting groupP6 is hydrogen or an amino protecting groups preferably an amino protecting groups andP8 is an amino protecting group.
